Article

Minimal effects of <i>spargel</i> (PGC-1α) overexpression in a <i>Drosophila</i> mitochondrial disease model

2019-01-26

Abstract excerpt

<h4>ABSTRACT</h4> PGC-1α and its homologues have been proposed to act as master regulators of mitochondrial biogenesis in animals. Most relevant studies have been conducted in mammals, where interpretation is complicated by the fact that there are three partially redundant members of the gene family. In Drosophila , only a single PGC-1α homologue, spargel ( srl ), is present in the genome. Here we analyzed the...

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Literature Corpus work: 8a89d18a-229a-56fa-a2ca-267e824801e2
DOI: 10.1101/529545

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