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Article

The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling.

The EMBO journal - 6 Jan 2010

Tiefenböck Stefanie K, Baltzer Claudia, Egli Nicole A, Frei Christian

Abstract excerpt

Mitochondrial mass and activity must be adapted to tissue function, cellular growth and nutrient availability. In mammals, the related transcriptional coactivators PGC-1alpha, PGC-1beta and PRC regulate multiple metabolic functions, including mitochondrial biogenesis. However, we know relatively little about their respective roles in vivo. Here we show that the Drosophila PGC-1 family homologue, Spargel, is...

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Identifiers

PMID: 19910925
DOI: 10.1038/emboj.2009.330
PMCID: PMC2808377

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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