Article
Nuclear genetic background influences the phenotype of the Drosophila tko25t mitochondrial protein-synthesis mutant.
G3 (Bethesda, Md.) - 1 Jun 2023
Jacobs Howard T, Tuomela Tea, Lillsunde Päivi
Abstract excerpt
The Drosophila tko25t point mutation in the gene encoding mitoribosomal protein S12 produces a complex phenotype of multiple respiratory chain deficiency, developmental delay, bang-sensitivity, impaired hearing, sugar and antibiotic sensitivity, and impaired male courtship. Its phenotypic severity was previously shown to be alleviated by inbreeding and to vary with mitochondrial genetic background. Here, we show...
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