Article
New mutant alleles for Spargel/dPGC-1 highlights the function of Spargel RRM domain in oogenesis and expands the role of Spargel in embryogenesis and intracellular transport.
G3 (Bethesda, Md.) - 30 Aug 2023
Roy Swagota D, Nagarajan Sabarish, Jalal Md Shah, Basar Md Abul, Duttaroy Atanu
Abstract excerpt
Energy metabolism in vertebrates is controlled by three members of the PGC-1 (PPAR γ- coactivator 1) family, transcriptional coactivators that shape responses to physiological stimuli by interacting with the nuclear receptors and other transcription factors. Multiple evidence now supports that Spargel protein found in insects and ascidians is the ancestral form of vertebrate PGC-1's. Here, we undertook functional...
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