Article

Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila

2019-09-04

Abstract excerpt

<title>Abstract</title> <p>Background: The transcriptional co-activators of the PGC-1 family have been proposed as master regulators of mitochondrial biogenesis. Drosophila has a single member of the family, Spargel (srl). Functional studies of srl allow PGC-1 role(s) in development and physiology to be elucidated without the confounding effects of tissue-specificity and redundancy. Spargel was previously shown t...

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Literature Corpus work: f0049fc1-4031-57ef-9ff2-56cd6c6e2be8
DOI: 10.21203/rs.2.10192/v1

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