Article

Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a <i>Drosophila</i> cachexia model

2023-06-24

Abstract excerpt

Cancer cachexia is a tumour-induced wasting syndrome, characterised by extreme loss of skeletal muscle. Defective mitochondria can contribute to muscle wasting; however, the underlying mechanisms remain unclear. Using a Drosophila larval model of cancer cachexia, we observed enlarged and dysfunctional muscle mitochondria. Morphological changes were accompanied by upregulation of beta-oxidation proteins and deplet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 34cc6103-9795-555b-91b1-0e2d24b07784
DOI: 10.1101/2023.06.23.546217

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a <i>Drosophila</i> cachexia modelDOI 10.1101/2023.06.23.546217Read

Mitochondrial dynamics in cancer-induced cachexiaSemantic proximity Read

<i>Drosophila</i> larval models of invasive tumourigenesis for in vivo studies on tumour/peripheral host tissue interactions during cancer cachexiaSemantic proximity Read

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia modelSemantic proximity Read

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice.Semantic proximity Read

Cancer as a systemic disease : investigating tumour-host interaction in DrosophilaSemantic proximity Read

Cancer cachexia: lessons from DrosophilaSemantic proximity Read

Systemic impact of the expression of the mitochondrial alternative oxidase on <i>Drosophila</i> developmentSemantic proximity Read

Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting.Semantic proximity Read

Time-restricted feeding promotes skeletal muscle function in diet- and genetic-induced obesity through shared and unique pathwaysSemantic proximity Read

Drosophila as a toolkit to tackle cancer and its metabolismSemantic proximity Read

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster.Semantic proximity Read

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in <i>Drosophila</i>Semantic proximity Read