Article

Identification of CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices

2023-10-27

Abstract excerpt

Mechanical properties of the extracellular matrix (ECM) critically regulate a number of important cell functions including growth, differentiation and migration. Type I collagen and glycosaminoglycans (GAGs) are two primary components of ECMs that contribute to mammalian tissue mechanics, with the collagen fiber network sustaining tension, and GAGs withstanding compression. The architecture and stiffness of the co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a843be7-c59e-5d8d-8337-3567ac0303a2
DOI: 10.1101/2023.10.24.563860

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matricesDOI 10.1101/2023.10.24.563860Read

High-Throughput Force Arrays Reveal Spatial Force Distribution as a Biomarker for Cancer Cell Identification and Drug Resistance DetectionSemantic proximity Read

Biomaterial-enabled delivery of SDF-1α at the ventral side of breast cancer cells reveals a crosstalk between cell receptors to promote the invasive phenotype.Semantic proximity Read

Mechanophenotyping of 3D Multicellular Clusters using Displacement Arrays of Rendered TractionsSemantic proximity Read

A novel method for sensor-based quantification of single/multi-cellular traction dynamics and remodeling in 3D matricesSemantic proximity Read

Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.Semantic proximity Read

Traction force dynamics during patient-derived glioblastoma neurosphere invasion in 3D MatrigelSemantic proximity Read

Measurement systems for cell adhesive forces.Semantic proximity Read

Vinculin Force Sensor Detects Tumor-Osteocyte InteractionsSemantic proximity Read

Modulating Three-Dimensional Microenvironment with Hyaluronan of Different Molecular Weights Alters Breast Cancer Cell Invasion BehaviorSemantic proximity Read

Endothelial cell traction and ECM density influence both capillary morphogenesis and maintenance in 3-D.Semantic proximity Read

Methotrexate-modulated talin-dynamics drives cellular mechanical phenotypes via YAP signalingSemantic proximity Read

The malignancy of metastatic ovarian cancer cells is increased on soft matrices through a mechanosensitive Rho-ROCK pathway.Semantic proximity Read