Article
Biomaterial-enabled delivery of SDF-1α at the ventral side of breast cancer cells reveals a crosstalk between cell receptors to promote the invasive phenotype.
Biomaterials - 1 May 2017
Liu Xi Qiu, Fourel Laure, Dalonneau Fabien, Sadir Rabia, Leal Salome, Lortat-Jacob Hugues, Weidenhaupt Marianne, Albiges-Rizo Corinne, Picart Catherine
Abstract excerpt
The SDF-1α chemokine (CXCL12) is a potent bioactive chemoattractant known to be involved in hematopoietic stem cell homing and cancer progression. The associated SDF-1α/CXCR4 receptor signaling is a hallmark of aggressive tumors, which can metastasize to distant sites such as lymph nodes, lung and bone. Here, we engineered a biomimetic tumoral niche made of a thin and soft polyelectrolyte film that can retain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.