Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulating Three-Dimensional Microenvironment with Hyaluronan of Different Molecular Weights Alters Breast Cancer Cell Invasion Behavior

27 Feb 2017

Abstract excerpt

Hyaluronan (HA), a polymer with various molecular weights (MW) found in tumor microenvironments, is associated with malignant progression of breast cancer. Reducing the amount of high-MW HA in the microenvironment by hyaluronidase is a promising approach for breast cancer treatment. However, whether the generation of HA fragments negatively affects breast cancer cells remains to be determined. Furthermore, HA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Fibroblast Growth Factor Research
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28240531
DOI: 10.1021/acsami.6b15187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulating Three-Dimensional Microenvironment with Hyaluronan of Different Molecular Weights Alters Breast Cancer Cell Invasion BehaviorPMID 28240531Read ↗

Breast cancer cells interact with tumor-derived extracellular matrix in a molecular subtype-specific mannerSemantic proximity Read ↗

Matrix-bound EGF promotes malignant phenotypes of breast cancer organoids in the biomimetic ECM of alginateSemantic proximity Read ↗

Harnessing Extracellular Matrix Biology for Tumor Drug DeliverySemantic proximity Read ↗

Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cellsSemantic proximity Read ↗

Mechanoregulation of Cancer-Associated Fibroblast Phenotype in Three-Dimensional Interpenetrating Hydrogel NetworksSemantic proximity Read ↗

The biomimetic extracellular matrix: a therapeutic tool for breast cancer researchSemantic proximity Read ↗

TGFβ and matrix-regulated epithelial to mesenchymal transitionSemantic proximity Read ↗

Biomaterial-enabled delivery of SDF-1α at the ventral side of breast cancer cells reveals a crosstalk between cell receptors to promote the invasive phenotype.Semantic proximity Read ↗

Tumor microenvironment remodeling modulates macrophage phenotype in breast cancer lymphangiogenesis.Semantic proximity Read ↗

The regulatory effect of hyaluronan on human mesenchymal stem cells’ fate modulates their interaction with cancer cells in vitroSemantic proximity Read ↗

The role of a new CD44st in increasing the invasion capability of the human breast cancer cell line MCF-7Semantic proximity Read ↗

Benchmarking to the Gold Standard: Hyaluronan‐Oxime Hydrogels Recapitulate Xenograft Models with In Vitro Breast Cancer Spheroid CultureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.