Article

A novel method for sensor-based quantification of single/multi-cellular traction dynamics and remodeling in 3D matrices

2020-09-25

Abstract excerpt

Cells in vivo generate mechanical forces (traction) on surrounding 3D extra cellular matrix (ECM) and cells. Such traction and biochemical cues may remodel the matrix, e.g. increase stiffness, which in turn influences cell functions and forces. This dynamic reciprocity mediates development and tumorigenesis. Currently, there is no method available to directly quantify single cell traction and matrix remodeling in...

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Identifiers and source

Literature Corpus work: 55fbad2c-92d3-5889-88e0-9b0581c85763
DOI: 10.1101/2020.09.24.311647

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