Article

Temporal-Spatial Visualization of Endogenous Chromosome Rearrangements in Living Cells

2019-08-13

Abstract excerpt

Visualizing the real-time dynamics of genome rearrangement in single living cells is core to studying genomics and diagnostics. Here, we report a robust, versatile approach named CRISPR Live -cell fluorescent in s itu h ybridization (LiveFISH) for multi-locus genome tracking and cytogenetic detection in a broad variety of cell types including primary cells. LiveFISH utilizes an intrinsic stability switch of CR...

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Literature Corpus work: 099da904-302c-5580-9dcf-4e1d39cc6c18
DOI: 10.1101/734483

Open publication

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