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Article

N-terminal serine/threonine motif has diverse and important effects on behavior of multiple AAV serotypes.

Virology - 1 Nov 2021

Chen Maria Y, Chen Weitong, Tong Jessica, Ho Michelle L, Suh Junghae

Abstract excerpt

Adeno-associated virus (AAV) is a promising gene therapy vector, but questions remain regarding mechanisms of basic viral functions. We previously showed that a serine/threonine (S/T) triplet motif and its flanking residues, located in the overlapping N-terminus of VP1/VP2 and highly conserved across most AAV serotypes, are critical for viral transcript production in vitro. Here we generate a panel of S/T triplet...

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Identifiers

PMID: 34509702
DOI: 10.1016/j.virol.2021.08.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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