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Article

Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages.

PLoS pathogens - 1 Jun 2024

Li Lirong, Qin Runkuan, Liu Yunbo, Tseng Yu-Shan, Zhang Weihan, Yu Lin, Mietzsch Mario, Zou Xinkai, Liu Haizhou, Lu Guangwen, Hu Hongbo, Mckenna Robert, Yang Jinliang, Wei Yuquan, Agbandje-Mckenna Mavis, Hu Jiankun, Yang Lin

Abstract excerpt

Adeno-associated virus (AAV) serotypes from primates are being developed and clinically used as vectors for human gene therapy. However, the evolutionary mechanism of AAV variants is far from being understood, except that genetic recombination plays an important role. Furthermore, little is known about the interaction between AAV and its natural hosts, human and nonhuman primates. In this study, natural AAV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38885242
DOI: 10.1371/journal.ppat.1012260
PMCID: PMC11182496

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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