Article

Alterations in chromosome spatial compartmentalization classify prostate cancer progression

2021-04-15

Abstract excerpt

Prostate cancer aggressiveness and metastatic potential are influenced by gene expression, genomic aberrations, and cellular morphology. These processes are in turn dependent in part on the 3D structure of chromosomes, packaged inside the nucleus. Using chromosome conformation capture (Hi-C), we conducted a systematic genome architecture comparison on a cohort of cell lines that model prostate cancer progression,...

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Literature Corpus work: 8a43f5db-7e44-5dbd-8f8a-e7c6c89f2d9f
DOI: 10.1101/2021.04.15.440056

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