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Chromosome compartmentalization alterations in prostate cancer cell lines model disease progression

18 Nov 2021

Abstract excerpt

Prostate cancer aggressiveness and metastatic potential are influenced by gene expression and genomic aberrations, features that can be influenced by the 3D structure of chromosomes inside the nucleus. Using chromosome conformation capture (Hi-C), we conducted a systematic genome architecture comparison on a cohort of cell lines that model prostate cancer progression, from normal epithelium to bone metastasis. We...

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PMID: 34889941
DOI: 10.1083/jcb.202104108

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