Article
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.
The lancet. Psychiatry - 1 Apr 2016
Ruderfer Douglas M, Charney Alexander W, Readhead Ben, Kidd Brian A, Kähler Anna K, Kenny Paul J, Keiser Michael J, Moran Jennifer L, Hultman Christina M, Scott Stuart A, Sullivan Patrick F, Purcell Shaun M, Dudley Joel T, Sklar Pamela
Abstract excerpt
BACKGROUND: Therapeutic treatments for schizophrenia do not alleviate symptoms for all patients and efficacy is limited by common, often severe, side-effects. Genetic studies of disease can identify novel drug targets, and drugs for which the mechanism has direct genetic support have increased likelihood of clinical success. Large-scale genetic studies of schizophrenia have increased the number of genes and gene...
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