Article

INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIA

2022-09-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Although murine models of coronary atherosclerotic disease (CAD) have been used extensively to determine mechanisms, limited new therapeutic options have emerged. Pigs with familial hypercholesterolemia (FH pigs) develop complex coronary atheromas that are almost identical to human lesions. We reported previously that insulin-like growth factor 1 (IGF-1) reduced aortic athero...

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Literature Corpus work: 8a38be07-0b91-5a44-addf-923762bc1611
DOI: 10.1101/2022.09.23.509213

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