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Article

Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.

Journal of the American Heart Association - 23 Mar 2018

Yuan Fang, Guo Liang, Park Kyoung-Ha, Woollard John R, Taek-Geun Kwon, Jiang Kai, Melkamu Tamene, Zang Bin, Smith Samantha L, Fahrenkrug Scott C, Kolodgie Frank D, Lerman Amir, Virmani Renu, Lerman Lilach O, Carlson Daniel F

Abstract excerpt

BACKGROUND: Ossabaw pigs are unique miniature swine with genetic predisposition to develop metabolic syndrome and coronary atherosclerosis after extended periods receiving atherogenic diets. We have hypothesized that transgenic Ossabaw swine expressing chimp PCSK9 (proprotein convertase subtilisin-like/kexin type 9) containing the D374Y gain of function would develop familial hypercholesterolemia and coronary...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29572319
DOI: 10.1161/JAHA.117.006207
PMCID: PMC5907533

Genes

PCSK9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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