Article
Development of complex atherosclerotic lesions in pigs with inherited hyper-LDL cholesterolemia bearing mutant alleles for apolipoprotein B.
The American journal of pathology - 1 Jul 1991
Prescott M F, McBride C H, Hasler-Rapacz J, Von Linden J, Rapacz J
Abstract excerpt
The development of atherosclerotic lesions was studied in pigs aged 4 to 54 months with inherited hyperlow-density lipoprotein (LDL) and hypercholesterolemia (IHLC pigs). These pigs bear the Lpb5 and Lpu1 mutant alleles for apolipoproteins B and U and demonstrate spontaneously elevated cholesterol levels, due primarily to elevated LDL. By 1 year of age, IHLC pigs exhibited focal lesions in the major coronary,...
Topics
- Aging
- Alleles
- Animals
- Apolipoproteins B
- Arteries
- Arteriosclerosis
- Cholesterol, LDL
- Hyperlipoproteinemia Type II
- Microscopy, Electron, Scanning
- Mutation
- Swine