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Article

Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs.

PloS one - 1 Jan 2014

Davis Bryan T, Wang Xiao-Jun, Rohret Judy A, Struzynski Jason T, Merricks Elizabeth P, Bellinger Dwight A, Rohret Frank A, Nichols Timothy C, Rogers Christopher S

Abstract excerpt

Recent progress in engineering the genomes of large animals has spurred increased interest in developing better animal models for diseases where current options are inadequate. Here, we report the creation of Yucatan miniature pigs with targeted disruptions of the low-density lipoprotein receptor (LDLR) gene in an effort to provide an improved large animal model of familial hypercholesterolemia and...

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Identifiers

PMID: 24691380
DOI: 10.1371/journal.pone.0093457
PMCID: PMC3972179

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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