Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans

11 Nov 2021

Abstract excerpt

Genetic variants in the asialoglycoprotein receptor 1 (ASGR1) are associated with a reduced risk of cardiovascular disease (CVD) in humans. However, the underlying molecular mechanism remains elusive. Given the cardiovascular similarities between pigs and humans, we generated ASGR1-deficient pigs using the CRISPR/Cas9 system. These pigs show age-dependent low levels of non-HDL-C under standard diet. When received...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis and Cardiovascular Diseases
Share to Cholesterol and Lipid Metabolism
Share to Lipoproteins and Cardiovascular Health

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34762653
DOI: 10.1371/journal.pgen.1009891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humansPMID 34762653Read ↗

CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels.Semantic proximity Read ↗

Loss of <i>asgr1a</i> leads to the secretion of excess dietary cholesterol in zebrafishSemantic proximity Read ↗

Asialoglycoprotein receptor subunit Asgr1a loss results in attenuated cholesterol absorption in zebrafish fed a western diet.Semantic proximity Read ↗

Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs.Semantic proximity Read ↗

ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE-/- mice.Semantic proximity Read ↗

Sexually Dimorphic Response to Hepatic Injury in Newborn Suffering from Intrauterine Growth RestrictionSemantic proximity Read ↗

INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIASemantic proximity Read ↗

Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study.Semantic proximity Read ↗

Swine Models of Type 2 Diabetes Mellitus: Insulin Resistance, Glucose Tolerance, and Cardiovascular ComplicationsSemantic proximity Read ↗

Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant.Semantic proximity Read ↗

Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studiesSemantic proximity Read ↗

The ApoE-Null Golden Hamster: A Novel Model of Atherosclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.