Article

SYVN1-mediated ubiquitylation directs the localization of MCT4 in plasma membrane to promote the progression of lung adenocarcinoma

2023-02-20

Abstract excerpt

<title>Abstract</title> <p>Tumor cells mainly generate energy from glycolysis that is commonly coupled with lactate production even under normoxic conditions. As one critical lactate transporter, monocarboxylate transporter 4 (MCT4) is highly expressed in glycolytic tissues like muscles and tumors. Overexpression of MCT4 is associated with poor prognosis for patients with various tumors. However, it remains large...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a31c28a-2efd-5a5b-9b2b-4a8153257b9e
DOI: 10.21203/rs.3.rs-2469718/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SYVN1-mediated ubiquitylation directs the localization of MCT4 in plasma membrane to promote the progression of lung adenocarcinomaDOI 10.21203/rs.3.rs-2469718/v1Read

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor MicroenvironmentSemantic proximity Read

The Transcription Factor TEAD4 Enhances Lung Adenocarcinoma Malignancy through Enhancing PKM2 Mediated GlycolysisSemantic proximity Read

FAM189A2 Activates Hippo Signaling Pathway by Abrogating WWP2-mediated LATS1 Ubiquitination, to Inhibit the Glycolysis and Proliferation Processes of Lung AdenocarcinomaSemantic proximity Read

MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1Semantic proximity Read

SNHG15 inhibits the tricarboxylic acid cycle and promotes HCC progression by facilitating the phosphorylation of PDK1 and PDHE1αSemantic proximity Read

AL355338 acts as an oncogenic lncRNA by interacting with protein ENO1 to regulate EGFR/AKT pathway in NSCLCSemantic proximity Read

HSF1-dependent augmentation of aerobic glycolysis by NEK2 fuels lung adenocarcinoma progressionSemantic proximity Read

The monocarboxylate transporter family--role and regulation.Semantic proximity Read

Pan-cancer analysis reveals the prognostic relevance of NUP54 and its association with HIF-1α-related glycolytic phenotypes in lung adenocarcinoma.Semantic proximity Read

Vesicle amine transport-1 regulates hepatocellular carcinoma progression by EGF-induced STAT3 signallingSemantic proximity Read

SFXN1 promotes bladder cancer metastasis by restraining PINK1-dependent mitophagySemantic proximity Read

Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomasSemantic proximity Read