Article

Glutamine stress promotes metastatic potential via hexosamine biosynthetic pathway activity in KRAS/STK11-mutant lung adenocarcinoma

2026-08-27

Abstract excerpt

<title>Abstract</title> <p>Lung cancer is the leading cause of cancer-related deaths worldwide. Loss of STK11 in KRAS-driven lung adenocarcinoma (LUAD) is observed in approximately 15,000 US lung cancer cases annually and drives an aggressive, resistant disease. STK11 regulates many cellular processes, including metabolism, and loss of this tumor suppressor drives a “glutamine addicted” phenotype that is being co...

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Literature Corpus work: c74c818c-aac4-565b-9b26-9f2014c5d7fa
DOI: 10.21203/rs.3.rs-10670097/v1

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