Article

The Transcription Factor TEAD4 Enhances Lung Adenocarcinoma Malignancy through Enhancing PKM2 Mediated Glycolysis

2020-11-26

Abstract excerpt

Lung adenocarcinoma (LUAD) is a deadly disease with a hallmark of aberrant metabolism. The role of TEAD4 in LUAD is rarely reported as well as its potential mechanisms. The expression level of TEAD4 and PKM2 was measured by quantitative real-time PCR and western blot. Luciferase reporter assay were employed to verify the effect of TEAD4 on PKM2 promoter as well as TEAD4/PKM2 axis on reporter activity of HIF-1α. Gl...

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Literature Corpus work: 448a12bd-760f-552d-95d3-7f61bf67e9fd
DOI: 10.1101/2020.11.25.399295

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