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SFXN1 promotes bladder cancer metastasis by restraining PINK1-dependent mitophagy

4 Jun 2025

Abstract excerpt

Sideroflexin 1 (SFXN1), a newly identified mitochondrial serine transporter, exhibits great potential to modulate mitochondrial function and promote tumor development. However, its role in bladder cancer (BLCA) remains unclear. Our study revealed that SFXN1 was enriched in clinical BLCA tissues, and high SFXN1 expression in BLCA was positively associated with the progression and poor prognosis. Further, SFXN1...

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PMID: 40468051
DOI: 10.1038/s41388-025-03460-7

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