Article

Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness

2020-10-30

Abstract excerpt

Cell cycle dysregulation is prerequisite for cancer formation. However, it is unknown whether the mode of dysregulation affects disease characteristics. Here, we conduct comprehensive analyses of cell cycle checkpoint dysregulation events in breast cancer using patient data complemented by experimental investigations in multiple model systems: genetically-engineered mice, patient-derived xenografts, biomatrices, a...

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Literature Corpus work: f3997ae2-2b53-5281-9e32-c99fc6777d93
DOI: 10.1101/2020.10.29.361352

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