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Versatile Design of Intracellular Protein-Responsive Translational Regulation System for Synthetic mRNA

21 Feb 2022

Abstract excerpt

Synthetic mRNA (mRNA) enables transgene expression without the necessity of nuclear import and the risk of insertional mutagenesis, which makes it an attractive tool for medical applications such as vaccination and protein replacement therapy. For further improvement of mRNA therapeutics, cell-selective translation is desirable, because transgene expression in nontarget cells sometimes causes adverse effects. In...

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PMID: 35188747
DOI: 10.1021/acssynbio.1c00567

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