Article
A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell.
Nucleic acids research - 10 Feb 2006
Wiesenthal Volker, Leutz Achim, Calkhoven Cornelis F
Abstract excerpt
Regulation of translation is critical for the accurate expression of a broad variety of genes that function in cell cycle progression and cell differentiation, as well as in the adaptation to cellular stress. The aetiologies of a number of human diseases, including cancer, have been linked to mutations in genes that control mRNA translation, or in cis-regulatory mRNA-sequences. Therefore, research on...
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