Article
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
The Journal of experimental medicine - 4 Dec 2017
Matsuzawa-Ishimoto Yu, Shono Yusuke, Gomez Luis E, Hubbard-Lucey Vanessa M, Cammer Michael, Neil Jessica, Dewan M Zahidunnabi, Lieberman Sophia R, Lazrak Amina, Marinis Jill M, Beal Allison, Harris Philip A, Bertin John, Liu Chen, Ding Yi, van den Brink Marcel R M, Cadwell Ken
Abstract excerpt
A variant of the autophagy gene ATG16L1 is associated with Crohn's disease, an inflammatory bowel disease (IBD), and poor survival in allogeneic hematopoietic stem cell transplant recipients. We demonstrate that ATG16L1 in the intestinal epithelium is essential for preventing loss of Paneth cells and exaggerated cell death in animal models of virally triggered IBD and allogeneic hematopoietic stem cell...
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