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Article

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.

Cell - 25 Jun 2010

Cadwell Ken, Patel Khushbu K, Maloney Nicole S, Liu Ta-Chiang, Ng Aylwin C Y, Storer Chad E, Head Richard D, Xavier Ramnik, Stappenbeck Thaddeus S, Virgin Herbert W

Abstract excerpt

It is unclear why disease occurs in only a small proportion of persons carrying common risk alleles of disease susceptibility genes. Here we demonstrate that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice. This virus-plus-susceptibility gene interaction generated abnormalities in granule packaging and...

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Identifiers

PMID: 20602997
DOI: 10.1016/j.cell.2010.05.009
PMCID: PMC2908380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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