Article

Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases

2025-04-03

Abstract excerpt

<h4>Background</h4> Enteric glial cells (EGC) play a crucial role in maintaining gut homeostasis, but their dysregulation in inflammatory bowel diseases (IBD) remains poorly understood. Emerging preclinical data suggests activated EGC have beneficial roles in controlling gut pathophysiology. <h4>Objective</h4> Understanding EGC activation and adaptation during experimental and clinical IBD. <h4>Design</h4> We p...

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Literature Corpus work: 76251a6a-2846-551f-9e3a-ab94d9f608fc
DOI: 10.1101/2025.04.03.646820

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