An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.

doi:10.1182/blood.2019004116

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An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.

Blood - 25 Jun 2020

Matsuzawa-Ishimoto Yu, Hine Ashley, Shono Yusuke, Rudensky Eugene, Lazrak Amina, Yeung Frank, Neil Jessica A, Yao Xiaomin, Chen Ying-Han, Heaney Thomas, Schuster Samantha L, Zwack Erin E, Axelrad Jordan E, Hudesman David, Tsai Jennifer J, Nichols Katherine, Dewan M Zahidunnabi, Cammer Michael, Beal Allison, Hoffman Sandra, Geddes Brad, Bertin John, Liu Chen, Torres Victor J, Loke P'ng, van den Brink Marcel R M, Cadwell Ken

Abstract excerpt

A goal in precision medicine is to use patient-derived material to predict disease course and intervention outcomes. Here, we use mechanistic observations in a preclinical animal model to design an ex vivo platform that recreates genetic susceptibility to T-cell-mediated damage. Intestinal graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation. We...

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PMID: 32232483
DOI: 10.1182/blood.2019004116
PMCID: PMC7317146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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