Article

<i>ninaD</i> regulates cholesterol homeostasis from the midgut which protects against neurodegeneration

2020-11-27

Abstract excerpt

<h4>SUMMARY</h4> Cholesterol is crucial to maintain normal cellular function. In human, it has also been involved in various neurodegeneration processes, as Niemann-Pick and Alzheimer diseases. Recently, we have identified a small nucleolar RNA ( jouvence ) required in the epithelial cells of the gut (enterocytes), and showed that its overexpression extends lifespan. A transcriptomic analysis has revealed a dere...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a05f585-596f-52e1-adde-f9226353edaf
DOI: 10.1101/2020.11.27.401059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>ninaD</i> regulates cholesterol homeostasis from the midgut which protects against neurodegenerationDOI 10.1101/2020.11.27.401059Read

<i>jouvence</i> , a new small nucleolar RNA required in the gut extends lifespan in DrosophilaSemantic proximity Read

A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neuronsSemantic proximity Read

Pseudouridylation of rRNA by specific snoRNA disrupts ribosomal machinery and consequently affects metabolism, longevity and neurodegenerationSemantic proximity Read

Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration.Semantic proximity Read

Severe neurometabolic phenotype in <i>npc1</i> <sup>-/-</sup> zebrafish with a C-terminal mutationSemantic proximity Read

A <i>Drosophila</i> Model of Pontocerebellar Hypoplasia Reveals a Critical Role for the RNA Exosome in NeuronsSemantic proximity Read

<i>jouvence</i> , a new human H/ACA snoRNA involves in the control of cell proliferation and differentiationSemantic proximity Read

Nazo, the <i>Drosophila</i> homolog of the NBIA-mutated protein – c19orf12, is required for triglyceride homeostasisSemantic proximity Read

Interplay of Spoonbill, Larp7 and survival motor neuron, in <i>Drosophila</i> model of Spinocerebellar Ataxia 8 non-coding RNA associated neurodegenerationSemantic proximity Read

Opposing steroid signals modulate protein homeostasis through deep changes in fat metabolism in <i>Caenorhabditis elegans</i>Semantic proximity Read

Loss of Drosophila NUS1 results in cholesterol accumulation and Parkinson’s disease‐related neurodegenerationSemantic proximity Read

A lysosomal surveillance response to stress extends healthspanSemantic proximity Read