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Article

Loss of Drosophila NUS1 results in cholesterol accumulation and Parkinson’s disease‐related neurodegeneration

13 Jun 2022

Abstract excerpt

NgBR is the Nogo-B receptor, encoded by NUS1 gene. As NgBR contains a C-terminal domain that is similar to cis-isoprenyltransferase (cis-IPTase), NgBR was speculated to stabilize nascent Niemann-Pick type C 2 (NPC2) to facilitate cholesterol transport out of lysosomes. Mutations in the NUS1 were known as risk factors for Parkinson's disease (PD). In our previous study, it was shown that knockdown of Drosophila...

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PMID: 35695805
DOI: 10.1096/fj.202200212r

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