Association between BDNF methylation and expression of the NLRP3 inflammasome in the brain is disrupted in Alzheimer’s disease

Abstract excerpt

<title>Abstract</title> <p>Activation of the NLRP3 inflammasome pathway and dysfunction of brain-derived neurotrophic factor (BDNF) are both implicated in the pathogenesis of Alzheimer's disease (AD). While in vitro and in vivo models support these mechanisms, there is little research investigating their relationship in human brain tissue, and whether this relationship may be abnormal in the AD brain. Temporal co...

Topics

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• Aged
• Brain-Derived Neurotrophic Factor
• Cognitive Dysfunction
• Matrix Metalloproteinase 9
• NLR Family, Pyrin Domain-Containing 3 Protein
• Oxidation-Reduction
• Oxidative Stress
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

8a057341-5ff2-5d18-834d-fec50b68933e

DOI

10.21203/rs.3.rs-9645218/v1