Article

TACR3 variant confers resilience to aging and Alzheimer’s disease

2026-06-08

Abstract excerpt

<h4>Background</h4> While genetic factors strongly influence brain aging trajectories, variants conferring cognitive resilience remain poorly characterized. The neurokinin-3 receptor (NK3-R), encoded by Tachykinin Receptor 3 ( TACR3) , modulates cholinergic signaling in memory circuits vulnerable to aging. Previous studies linked the non-WT expression of the TACR3 variant rs2765 with cognitive decline and reduc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e38e6d95-eba8-59ae-a14a-a22666152dd3
DOI: 10.64898/2026.06.06.26355071

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TACR3 variant confers resilience to aging and Alzheimer’s diseaseDOI 10.64898/2026.06.06.26355071Read

Association of a neurokinin 3 receptor polymorphism with the anterior basal forebrain.Semantic proximity Read

Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.Semantic proximity Read

Genetic signature of human longevity in PKC and NF-κB signaling.Semantic proximity Read

Rare genetic coding variants associated with age-related episodic memory decline implicate distinct memory pathologies in the hippocampusSemantic proximity Read

Associations of MAP2K3 Gene Variants With Superior Memory in SuperAgersSemantic proximity Read

<i>CHRNA5</i> links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s DiseaseSemantic proximity Read

Genetics of transient amnesia highlights a vascular role in memorySemantic proximity Read

Association of common KIBRA variants with episodic memory and AD risk.Semantic proximity Read

NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosisSemantic proximity Read

Genetic variants associated with age-related episodic memory decline implicate distinct memory pathologies.Semantic proximity Read

A protective role for the cerebellum in cognitive agingSemantic proximity Read

Transcriptional alteration in TRKβ-SHC isoform as a neuroprotective factor for post stroke memory outcomeSemantic proximity Read