Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional significance of NLRP3 polymorphisms in mild cognitive impairment.

BMC geriatrics - 8 Jan 2026

Gao Ruonan, Lam Linda Chiu Wa, Lee Allen Ting Chun, Tang Nelson Leung Sang, Ma Suk Ling

Abstract excerpt

BACKGROUND: Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) inflammasome is an essential component of the innate immune system and regulates inflammation. NLRP3 inflammasome has been widely studied in the pathogenesis of mild cognitive impairments (MCI) and Alzheimer’s Disease (AD). Single nucleotide polymorphisms (SNPs) of NLRP3 gene are associated with various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Cognitive Dysfunction
Share to NLRP3 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41507841
DOI: 10.1186/s12877-025-06905-6
PMCID: PMC12882300

Genes

NLRP3
CASP1
PYCARD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional significance of NLRP3 polymorphisms in mild cognitive impairment.PMID 41507841Read ↗

The association of NLRP3 polymorphisms and its downstream interaction in mild cognitive impairmentSemantic proximity Read ↗

NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosisSemantic proximity Read ↗

A systematic review on the association between inflammatory genes and cognitive decline in non-demented elderly individuals.Semantic proximity Read ↗

Human Leukocyte Antigen and microRNAs as Key Orchestrators of Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.Semantic proximity Read ↗

NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosisSemantic proximity Read ↗

Circulating long noncodingRNAs in Mild Cognitive Impairment patients’ bloodSemantic proximity Read ↗

CHI3L1 drives astrocyte-medicated neuronal injury via GAL3-NLRP3 signaling in ischemic strokeSemantic proximity Read ↗

The association of Alzheimer's disease-related SNPs with mild cognitive impairment susceptibility in the Chinese population.Semantic proximity Read ↗

Common Variant in PLD3 Influencing Cerebrospinal Fluid Total Tau Levels and Hippocampal Volumes in Mild Cognitive Impairment Patients from the ADNI Cohort.Semantic proximity Read ↗

The Association of Calcium Signaling Pathway Gene Variants, Bone Mineral Density and Mild Cognitive Impairment in Elderly People.Semantic proximity Read ↗

The current role of NLRP3 inflammasome polymorphism in gout susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.