Article

Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice

2020-05-15

Abstract excerpt

<title>Abstract</title> <p><italic>Background</italic> : An association between neuroinflammation and age-related neurologic disorders has been established but the molecular mechanisms and cell types involved have not been thoroughly characterized. Activity of the proinflammatory NLRP3 inflammasome is implicated in Alzheimer’s and Parkinson’s disease and our recent studies in patients suggest that dopaminergic ne...

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Literature Corpus work: f8fed8a4-b2f2-586a-b852-208601013a25
DOI: 10.21203/rs.2.20931/v2

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