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Article

Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease

4 Mar 2015

Abstract excerpt

BACKGROUND/AIMS: In the present study, we examined whether DNA methylation of the brain-derived neurotrophic factor (BDNF) promoter is associated with the manifestation and clinical presentation of Alzheimer's disease (AD). METHODS: Of 20 patients with AD and 20 age-matched normal controls (NCs), the DNA methylation of the BDNF promoter (measured using peripheral blood samples) was completely analyzed in 12...

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PMID: 25873928
DOI: 10.1159/000375367

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