Article
Redox dysregulation, immuno-inflammatory alterations and genetic variants of BDNF and MMP-9 in schizophrenia: Pathophysiological and phenotypic implications.
Schizophrenia research - 1 Oct 2017
Ali Fahmy T, Abd El-Azeem Eman M, Hamed Marwa A, Ali Mohamed A M, Abd Al-Kader Nour M, Hassan Ekrami A
Abstract excerpt
BACKGROUND: Although a clear mechanism underlying the pathophysiology of schizophrenia (SZ) remains elusive, oxidative stress, inflammatory syndrome and immune activation have become an attractive hypothesis for explaining the pathophysiology of SZ. Data from prior studies on the role of matrix metalloproteinase 9 (MMP-9) and brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms (SNPs) in SZ...
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