Article

Conformation-specific Design: a New Benchmark and Algorithm with Application to Engineer a Constitutively Active Map Kinase

2025-04-24

Abstract excerpt

<h4> A bstract </h4> A general method for designing proteins with high conformational specificity is desirable for a variety of applications, including enzyme design and drug target redesign. To assess the ability of algorithms to design for conformational specificity, we introduce MotifDiv, a benchmark dataset of 200 conformational specificity design challenges. We also introduce CSDesign, an algorithm for des...

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Literature Corpus work: 89f78198-99f3-57a2-a47b-3e1c8806226b
DOI: 10.1101/2025.04.23.650138

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