Article

An optimal set of inhibitors for Reverse Engineering via Kinase Regularization

2020-09-28

Abstract excerpt

We present a comprehensive resource of 257 kinase inhibitor profiles against 365 human protein kinases using gold-standard kinase activity assays. We show the utility of this dataset with an improved version of Kinome Regularization (KiR) to deconvolve protein kinases involved in a cellular phenotype. We assayed protein kinase inhibitors against more than 70% of the human protein kinome and chose an optimal subset...

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Literature Corpus work: ab7635e8-3a96-5cb7-b5a1-871a34067a6b
DOI: 10.1101/2020.09.26.312348

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