Article

Protein Sequence Design with a Learned Potential

2020-01-07

Abstract excerpt

<h4> A bstract </h4> The task of protein sequence design is central to nearly all rational protein engineering problems, and enormous effort has gone into the development of energy functions to guide design. We investigate the capability of a deep neural network model to automate design of sequences onto protein backbones, having learned directly from crystal structure data and without any human-specified prior...

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Literature Corpus work: 4980c6a6-7175-5450-89ce-fb0ea8bf9a81
DOI: 10.1101/2020.01.06.895466

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