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Glucocorticoids rapidly modulate Ca <sub>V</sub> 1.2-mediated calcium signals through Kv2.1 channel clusters in hippocampal neurons

2023-12-25

Abstract excerpt

The precise regulation of Ca 2+ signals plays a crucial role in the physiological functions of neurons. Here, we investigated the rapid effect of glucocorticoids on Ca 2+ signals in hippocampal neurons. In cultured hippocampal neurons, glucocorticoids inhibited the spontaneous somatic Ca 2+ spikes generated by Kv2.1-organized Ca 2+ microdomains. Furthermore, glucocorticoids rapidly reduced the cell surface exp...

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Identifiers and source

Literature Corpus work
89f6f347-611e-57d7-9a12-b0274aab3f8d
DOI
10.1101/2023.12.24.573220
Open publication

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Glucocorticoids rapidly modulate Ca <sub>V</sub> 1.2-mediated calcium signals through Kv2.1 channel clusters in hippocampal neuronsDOI 10.1101/2023.12.24.573220
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