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Article

Cholesterol enhances neuron susceptibility to apoptotic stimuli via cAMP/PKA/CREB-dependent up-regulation of Kv2.1.

Journal of neurochemistry - 1 Feb 2012

Zhou Meng-Hua, Yang Guang, Jiao Song, Hu Chang-Long, Mei Yan-Ai

Abstract excerpt

Cholesterol is a major component of membrane lipid rafts. It is more abundant in the brain than in other tissues and plays a critical role in maintaining brain function. We report here that a significant enhancement in apoptosis in rat cerebellar granule neurons (CGNs) was observed upon incubation with 5mM K(+) /serum free (LK-S) medium. Cholesterol enrichment further potentiated CGN apoptosis incubated under...

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Source

Identifiers

PMID: 22118516
DOI: 10.1111/j.1471-4159.2011.07593.x

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CGN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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