Article

GPCR endocytosis rewires neuronal gene expression and cellular architecture

2025-08-28

Abstract excerpt

In the brain, G protein-coupled receptors (GPCRs) regulate neuronal excitability, synaptic transmission, and behavior by engaging transcriptional and translational programs that produce enduring changes in cellular function and architecture. However, the molecular mechanisms that couple GPCR activation to these adaptations remain poorly understood. Here, we demonstrate that the beta-adrenergic receptor (β2AR), a m...

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Literature Corpus work: 159a5913-294e-5fda-96a5-4f45402b7418
DOI: 10.1101/2025.08.26.672159

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