Article
Estrogens directly potentiate neuronal L-type Ca2+ channels.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2008
Sarkar Saumyendra N, Huang Ren-Qi, Logan Shaun M, Yi Kun Don, Dillon Glenn H, Simpkins James W
Abstract excerpt
L-type voltage-gated Ca(2+)channels (VGCC) play an important role in dendritic development, neuronal survival, and synaptic plasticity. Recent studies have demonstrated that the gonadal steroid estrogen rapidly induces Ca(2+) influx in hippocampal neurons, which is required for neuroprotection and potentiation of LTP. The mechanism by which estrogen rapidly induces this Ca(2+) influx is not clearly understood. We...
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