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Asparagine residue 368 is involved in Alzheimer's disease tau strain–specific aggregation

6 Aug 2020

Abstract excerpt

In tauopathies, tau forms pathogenic fibrils with distinct conformations (termed "tau strains") and acts as an aggregation "seed" templating the conversion of normal tau into isomorphic fibrils. Previous research showed that the aggregation core of tau fibril covers the C-terminal region (243–406 amino acids (aa)) and differs among the diseases. However, the mechanisms by which distinct fibrous structures are...

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PMID: 32759167
DOI: 10.1074/jbc.ra120.013271

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