Article

Tau AD fragment aggregates proliferate through autocatalytic secondary nucleation

2021-04-07

Abstract excerpt

<title>Abstract</title> <p>The self-assembly of the protein tau into neurofibrillary tangles is one of the hallmarks of Alzheimer’s disease and related tauopathies. Still, the molecular mechanism of tau aggregation is largely unknown. This problem may be addressed by systematically obtaining reproducible in vitro kinetic measurements under quiescent conditions in the absence of triggering substances. Here, we imp...

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Literature Corpus work: 247c70aa-2c0f-508f-bcdc-3e8caa46084c
DOI: 10.21203/rs.3.rs-351489/v1

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