Article

The FHA domain is essential for the autoinhibition of KIF1A/UNC-104

2023-12-24

Abstract excerpt

KIF1A/UNC-104, a member of the kinesin super family motor proteins, plays a pivotal role in the axonal transport of synaptic vesicles and their precursors. Drosophila melanogaster UNC-104 (DmUNC-104) is a relatively recently discovered Drosophila kinesin. Although some point mutations that disrupt synapse formation have been identified, the biochemical properties of DmUNC-104 protein have not been investigated....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89d3fae0-1ad3-58ce-b946-9aa243dda087
DOI: 10.1101/2023.12.24.573241

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The FHA domain is essential for the autoinhibition of KIF1A/UNC-104DOI 10.1101/2023.12.24.573241Read

<i>De novo</i> mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursorsSemantic proximity Read

Characterizing Human KIF1Bß Motor Activity by Single-Molecule Motility Assays and <i>Caenorhabtidis elegans</i> GeneticsSemantic proximity Read

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in NeuronsSemantic proximity Read

Autoinhibition of a Neuronal Kinesin UNC-104/KIF1A Regulates the Size and Density of Synapses.Semantic proximity Read

A plant flavonol and genetic suppressors rescue a pathogenic mutation associated with kinesin in neurons.Semantic proximity Read

Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model.Semantic proximity Read

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-bindingSemantic proximity Read

Distinct Clinical Phenotypes in KIF1A-Associated Neurological Disorders Result from Different Amino Acid Substitutions at the Same Residue in KIF1A.Semantic proximity Read

A systems-level proteomic analysis identifies kinesin targets of KIFBP during neuronal developmentSemantic proximity Read

The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.Semantic proximity Read

Modeling the motion of disease-associated KIF1A heterodimersSemantic proximity Read

Characterizing human KIF1Bβ motor activity by single-molecule motility assays and Caenorhabditis elegans genetics.Semantic proximity Read